GIPC3

Across TCGA cell cohorts, GIPC3 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GIPC3-associated genes across cancer lineages are CST9L, OR5M8, and OR8K3. Each is linked with GIPC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIPC3-to-partner and partner-to-GIPC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST9L grouped by GIPC3-low versus GIPC3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIPC3→partner) and Y-score (partner→GIPC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CST9L →	+0.017	+5.357	<.001	.001	3	1
CNS	OR5M8 →	+0.017	+4.754	<.001	.005	3	1
CNS	OR8K3 →	+0.009	+4.754	<.001	.005	3	1
BLOOD_Lymphoma	OR6C68 →	+0.068	+5.209	<.001	.005	3	1
BLOOD_Leukemia	GHRHR →	+0.312	+4.121	<.001	<.001	3	1
BLOOD_Leukemia	IL4 →	+1.757	+4.007	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

CST9L by GIPC3 expression — CNS

Explore this box plot interactively →