GIPC1

Across TCGA cell cohorts, GIPC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,091 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GIPC1-associated GO terms across cancer lineages are Rho protein signal transduction, Negative regulation of actin filament depolymerization, and Positive regulation of protein localization to membrane. Each is linked with GIPC1 in more than 12 cancer types. Because this analysis shows association rather than direction, both GIPC1-to-partner and partner-to-GIPC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rho protein signal transduction grouped by GIPC1-low versus GIPC1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GIPC1→partner) and Y-score (partner→GIPC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Rho protein signal transduction →	+0.132	+0.889	<.001	<.001	3	13
LUNG_NSCLC_LUAD	Negative regulation of actin filament depolymerization →	+0.208	+1.088	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Positive regulation of protein localization to membrane →	+0.123	+1.051	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of protein-containing complex assembly →	+0.094	+1.224	<.001	<.001	3	12
BONE	Regulation of intracellular transport →	+0.046	+0.717	.001	<.001	3	12
OESOPHAGUS	Regulation of Rho protein signal transduction →	+0.112	+0.973	.004	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,091 associations by consensus.

Rho protein signal transduction by GIPC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →