GIP

Across TCGA cell cohorts, GIP RNA expression is significantly associated with the go_rna of many other GO terms, with 876 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GIP-associated GO terms across cancer lineages are Alpha-beta T cell activation involved in immune response, T cell differentiation involved in immune response, and Regulation of intestinal cholesterol absorption. Each is linked with GIP in more than 3 cancer types. Because this analysis shows association rather than direction, both GIP-to-partner and partner-to-GIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Alpha-beta T cell activation involved in immune response grouped by GIP-low versus GIP-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GIP→partner) and Y-score (partner→GIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Alpha-beta T cell activation involved in immune response →	+0.078	+0.244	<.001	.007	3	4
LUNG_NSCLC_LUAD	T cell differentiation involved in immune response →	+0.078	+0.244	<.001	.007	3	4
LUNG_NSCLC_LUAD	Regulation of intestinal cholesterol absorption →	+0.125	+0.259	.002	.004	3	4
LUNG_NSCLC_LUAD	Linoleic acid metabolic process →	+0.144	+0.410	.001	.001	3	4
SKIN	Negative regulation of cell fate commitment →	+0.196	+0.035	<.001	.003	3	4
SKIN	Lactate metabolic process →	+0.064	+0.029	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 876 associations by consensus.

Alpha-beta T cell activation involved in immune response by GIP expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →