GINS3

Across TCGA pan-cancer cohorts, GINS3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GINS3 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GINS3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GINS3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where GINS3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	1.000	0.576	.001	34	view →
LUAD	DFS	Median	III,IV	0.767	0.270	.001	24	view →
PDAC	OS	Median	All	0.775	0.915	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GINS3–LSCC (OS)

Open the LSCC breakdown →