GINS3

Across TCGA patient cohorts, GINS3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GINS3-associated genes across cancer lineages are p27_pT198, Acetyl-a-Tubulin-Lys40, and IRS1. Each is linked with GINS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GINS3-to-partner and partner-to-GINS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by GINS3-low versus GINS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GINS3→partner) and Y-score (partner→GINS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.120	+3.000	.020	.036	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.621	+3.009	.011	.019	3	1
UCEC	IRS1 →	+0.303	+2.459	.002	.020	3	1
UCEC	MEK1 →	+0.386	+3.000	.029	.036	3	1
UCEC	MIG-6 →	+0.118	+2.472	.014	.011	3	1
UCEC	MSH6 →	-0.404	-2.999	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

p27_pT198 by GINS3 expression — UCEC

Explore this box plot interactively →