GINS3

Across TCGA cell cohorts, GINS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,895 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GINS3-associated GO terms across cancer lineages are DNA replication initiation, Regulation of cell cycle checkpoint, and Negative regulation of cell cycle process. Each is linked with GINS3 in more than 19 cancer types. Because this analysis shows association rather than direction, both GINS3-to-partner and partner-to-GINS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by GINS3-low versus GINS3-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GINS3→partner) and Y-score (partner→GINS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA replication initiation →	+0.195	+1.593	<.001	<.001	3	20
OVARY	Regulation of cell cycle checkpoint →	+0.103	+0.966	<.001	<.001	3	19
BLOOD_Myeloma	Negative regulation of cell cycle process →	+0.061	+1.280	.002	.001	3	18
SOFT_TISSUE	Negative regulation of cell cycle phase transition →	+0.069	+1.163	<.001	<.001	3	18
OESOPHAGUS	DNA-templated DNA replication maintenance of fidelity →	+0.114	+1.162	<.001	<.001	3	18
OESOPHAGUS	DNA-templated DNA replication →	+0.146	+1.237	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,895 associations by consensus.

DNA replication initiation by GINS3 expression — BLOOD_Myeloma

Explore this box plot interactively →