GINS1

Across TCGA pan-cancer cohorts, GINS1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GINS1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GINS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GINS1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where GINS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.888	0.577	<.001	31	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.625	.004	26	view →
PDAC	OS	Tertile	All	0.872	0.546	.005	24	view →
GBM	DFS	Median	All	0.422	0.206	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GINS1–CCRCC (DFS)

Open the CCRCC breakdown →