GINS1

Across TCGA patient cohorts, GINS1 mutation is significantly associated with the RNA expression of many other genes, with 361 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GINS1-associated genes across cancer lineages are RN7SKP181, RN7SL354P, and FCGR1A. Each is linked with GINS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GINS1-to-partner and partner-to-GINS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by GINS1-low versus GINS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GINS1→partner) and Y-score (partner→GINS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP181 →	+0.149	+2.963	<.001	.003	3	2
UCEC	RN7SL354P →	+0.283	+2.596	<.001	.001	3	2
UCEC	FCGR1A →	+0.925	+3.483	<.001	.002	3	1
UCEC	PITPNC1 →	+0.765	+3.584	.002	.003	3	1
UCEC	SLC7A7 →	+0.864	+3.507	.001	.002	3	1
UCEC	NTAN1 →	+0.627	+3.346	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 361 associations by consensus.

RN7SKP181 by GINS1 expression — UCEC

Explore this box plot interactively →