GINS1

Across TCGA patient cohorts, GINS1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GINS1-associated genes across cancer lineages are FoxM1, Gab2, and JNK_pT183_Y185. Each is linked with GINS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GINS1-to-partner and partner-to-GINS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by GINS1-low versus GINS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GINS1→partner) and Y-score (partner→GINS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.323	+2.321	.012	.035	3	1
UCEC	Gab2 →	+0.406	+2.321	.023	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.195	-2.308	.021	.036	3	1
UCEC	mTOR_pS2448 →	-0.190	-3.150	.011	.019	3	1
UCEC	PDCD4 →	-0.897	-3.459	<.001	.005	3	1
UCEC	Rictor_pT1135 →	-0.130	-2.999	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

FoxM1 by GINS1 expression — UCEC

Explore this box plot interactively →