GIN1

Across TCGA cell cohorts, GIN1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GIN1-associated genes across cancer lineages are SPPL2C, MAGEB5, and KRT71. Each is linked with GIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIN1-to-partner and partner-to-GIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPPL2C grouped by GIN1-low versus GIN1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIN1→partner) and Y-score (partner→GIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPPL2C →	+0.119	+3.604	<.001	.004	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Leukemia	KRT71 →	+0.066	+4.922	<.001	.009	3	1
BLOOD_Leukemia	TRIM60 →	+0.039	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP4-9 →	+0.055	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR6B1 →	+0.013	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SPPL2C by GIN1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →