GIMD1

Across TCGA patient cohorts, GIMD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,316 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible GIMD1-associated GO terms across cancer lineages are Vacuolar acidification, Ectoderm development, and Regulation of protein deubiquitination. Each is linked with GIMD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GIMD1-to-partner and partner-to-GIMD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vacuolar acidification grouped by GIMD1-low versus GIMD1-high in KIRP.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GIMD1→partner) and Y-score (partner→GIMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	Vacuolar acidification →	+0.041	+0.023	.002	.006	3	3
SKCM	Ectoderm development →	+0.035	+0.037	<.001	.002	3	3
LAML	Regulation of protein deubiquitination →	+0.065	+0.188	<.001	.001	3	3
LGG	Negative regulation of ubiquitin-protein transferase activity →	+0.032	+0.030	<.001	<.001	3	3
HNSC	Regulation of Wnt signaling pathway involved in heart development →	+0.050	+0.033	.006	.001	3	2
LAML	Interferon-mediated signaling pathway →	+0.041	+0.119	.004	.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,316 associations by consensus.

Vacuolar acidification by GIMD1 expression — KIRP

Explore this box plot interactively →