GIMAP8

Across TCGA pan-cancer cohorts, GIMAP8 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated GIMAP8 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher GIMAP8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GIMAP8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

CESC, OV, and ESCA are the cancer types where GIMAP8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.142	0.801	<.001	36	view →
OV	DFS	Median	All	0.263	0.543	.002	30	view →
ESCA	OS	Median	II,III,IV	0.136	0.703	<.001	24	view →
UCEC	DFS	Median	II,III,IV	0.922	0.436	.023	16	view →
LGG	OS	Median	All	0.208	0.889	<.001	6	view →
SKCM	OS	Median	III,IV	0.919	0.795	.020	5	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

GIMAP8–CESC (OS)

Open the CESC breakdown →