GIMAP8

Across TCGA patient cohorts, GIMAP8 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIMAP8-associated genes across cancer lineages are C-Raf, GSK-3_pS9, and GSK-3a-b_pS21_S9. Each is linked with GIMAP8 in more than 2 cancer types. Because this analysis shows association rather than direction, both GIMAP8-to-partner and partner-to-GIMAP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by GIMAP8-low versus GIMAP8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIMAP8→partner) and Y-score (partner→GIMAP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.198	+2.087	<.001	.005	3	3
COAD	GSK-3_pS9 →	-0.518	-3.450	.003	.005	3	2
COAD	GSK-3a-b_pS21_S9 →	-0.408	-3.433	.021	.005	3	2
COAD	Akt_pS473 →	-0.433	-2.313	.028	.035	3	2
COAD	Bad_pS112 →	-0.238	-3.450	.007	.005	3	2
SKCM	TFRC →	+0.505	+3.000	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

C-Raf by GIMAP8 expression — UCEC

Explore this box plot interactively →