GIMAP8

Across TCGA cell cohorts, GIMAP8 mutation is significantly associated with the RNA expression of many other genes, with 170 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GIMAP8-associated genes across cancer lineages are C1QBP, ALKBH2, and USP17L15. Each is linked with GIMAP8 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIMAP8-to-partner and partner-to-GIMAP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QBP grouped by GIMAP8-low versus GIMAP8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIMAP8→partner) and Y-score (partner→GIMAP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C1QBP →	+0.456	+2.451	.005	<.001	3	2
LARGE_INTESTINE	ALKBH2 →	+1.046	+3.212	<.001	.006	3	2
LUNG_NSCLC_LUSC	USP17L15 →	+0.006	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	GAGE12J →	+0.266	+4.643	<.001	.008	3	1
SKIN	RPL28 →	+0.450	+3.459	.002	.001	3	1
SKIN	LAMA5 →	-1.263	-2.106	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 170 associations by consensus.

C1QBP by GIMAP8 expression — SKIN

Explore this box plot interactively →