GIMAP6

Across TCGA patient cohorts, GIMAP6 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIMAP6-associated genes across cancer lineages are p38-MAPK, FOXO3a_pS318_S321, and Notch1. Each is linked with GIMAP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIMAP6-to-partner and partner-to-GIMAP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK grouped by GIMAP6-low versus GIMAP6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIMAP6→partner) and Y-score (partner→GIMAP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p38-MAPK →	-0.120	-1.584	.022	.032	3	1
UCEC	FOXO3a_pS318_S321 →	-0.144	-3.312	.013	.010	3	1
UCEC	Notch1 →	+0.176	+3.179	.007	.010	3	1
UCEC	p62 Lck ligand →	+0.351	+2.179	.020	.034	3	1
UCEC	Cyclin-B1 →	+0.682	+2.584	.009	.011	2	2
UCEC	Caspase-8 →	-0.248	-3.169	.034	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p38-MAPK by GIMAP6 expression — SKCM

Explore this box plot interactively →