GIMAP4

Across TCGA pan-cancer cohorts, GIMAP4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GIMAP4 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GIMAP4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GIMAP4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

COAD, LUAD, and HNSC are the cancer types where GIMAP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.867	1.000	.010	84	view →
LUAD	DFS	Tertile	All	0.823	0.477	<.001	11	view →
HNSC	DFS	Quartile	All	0.866	1.000	.006	9	view →
LSCC	DFS	Quartile	II,III,IV	0.541	0.933	.017	8	view →
UCEC	DFS	Quartile	II,III,IV	0.313	0.872	.024	8	view →
GBM	OS	Tertile	All	0.383	0.606	.011	2	view →
CCRCC	DFS	Tertile	II,III,IV	0.752	0.507	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GIMAP4–COAD (DFS)

Open the COAD breakdown →