GIMAP4

Across TCGA patient cohorts, GIMAP4 mutation is significantly associated with the RNA expression of many other genes, with 682 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIMAP4-associated genes across cancer lineages are RNA5SP70, CCNB2, and CHAF1A. Each is linked with GIMAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIMAP4-to-partner and partner-to-GIMAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP70 grouped by GIMAP4-low versus GIMAP4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIMAP4→partner) and Y-score (partner→GIMAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP70 →	+0.330	+7.731	<.001	.009	3	2
UCEC	CCNB2 →	+0.732	+3.491	.005	.002	3	2
UCEC	CHAF1A →	+0.615	+2.828	.003	.001	3	2
UCEC	SLC49A3 →	-0.773	-2.785	.004	.003	3	2
UCEC	RAD51 →	+0.708	+3.467	.003	.002	3	2
UCEC	TCF3 →	+0.658	+3.499	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 682 associations by consensus.

RNA5SP70 by GIMAP4 expression — BRCA

Explore this box plot interactively →