GIMAP4

Across TCGA patient cohorts, GIMAP4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIMAP4-associated genes across cancer lineages are FoxM1, Cyclin-B1, and GATA3. Each is linked with GIMAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIMAP4-to-partner and partner-to-GIMAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by GIMAP4-low versus GIMAP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIMAP4→partner) and Y-score (partner→GIMAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.246	+3.700	.041	.001	3	2
UCEC	Cyclin-B1 →	+0.707	+3.700	.006	.001	3	2
SKCM	GATA3 →	-0.172	-1.857	.016	.047	3	2
LUAD	4E-BP1_pT70 →	+0.277	+2.824	.012	.036	3	1
UCEC	INPP4B →	-0.328	-2.321	.029	.034	3	1
UCEC	Notch1 →	+0.248	+2.584	<.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

FoxM1 by GIMAP4 expression — UCEC

Explore this box plot interactively →