GIMAP4

Across TCGA cell cohorts, GIMAP4 mutation is significantly associated with the RNA expression of many other genes, with 79 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GIMAP4-associated genes across cancer lineages are SLC2A7, KLHL1, and BPIFC. Each is linked with GIMAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIMAP4-to-partner and partner-to-GIMAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC2A7 grouped by GIMAP4-low versus GIMAP4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIMAP4→partner) and Y-score (partner→GIMAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC2A7 →	+0.203	+4.222	<.001	.007	3	1
SKIN	KLHL1 →	+0.011	+4.376	<.001	<.001	3	1
SKIN	BPIFC →	+0.604	+3.772	<.001	.007	3	1
SKIN	PPIAL4E →	+0.049	+3.347	<.001	.005	3	1
BLOOD_Leukemia	ZP2 →	+0.161	+4.409	<.001	.005	3	1
BLOOD_Leukemia	TRIM51 →	+0.055	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

SLC2A7 by GIMAP4 expression — SOFT_TISSUE

Explore this box plot interactively →