GIMAP2

Across TCGA patient cohorts, GIMAP2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GIMAP2-associated genes across cancer lineages are eIF4E, ERK2, and JNK2. Each is linked with GIMAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIMAP2-to-partner and partner-to-GIMAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GIMAP2-low versus GIMAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIMAP2→partner) and Y-score (partner→GIMAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.222	+3.584	.029	.002	3	1
UCEC	ERK2 →	+0.257	+3.169	.005	.019	3	1
UCEC	JNK2 →	+0.211	+3.026	.028	.018	3	1
UCEC	Tuberin_pT1462 →	+0.230	+3.009	.039	.019	3	1
SKCM	Stathmin →	+0.147	+3.000	.015	.034	3	1
UCEC	Tuberin →	+0.353	+3.179	.006	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

eIF4E by GIMAP2 expression — UCEC

Explore this box plot interactively →