Across TCGA cell cohorts, GIGYF2 mutation is significantly associated with the RNA expression of many other genes, with 291 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GIGYF2-associated genes across cancer lineages are TRIM49C, SPINK6, and PF4V1. Each is linked with GIGYF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GIGYF2-to-partner and partner-to-GIGYF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GIGYF2→partner) and Y-score (partner→GIGYF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TRIM49C →	+0.008	+2.874	.003	.008	3	2
PANCREAS	SPINK6 →	+0.607	+4.087	.005	.001	3	2
CNS	PF4V1 →	+0.829	+4.832	<.001	.002	3	2
CNS	MTRNR2L10 →	+0.012	+5.357	<.001	.001	3	2
LUNG_NSCLC_LUAD	WFDC8 →	+0.010	+3.604	<.001	.004	3	2
LARGE_INTESTINE	TSPY2 →	+0.024	+2.824	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 291 associations by consensus.

Exploration

GIGYF2 survival (RNA) · tumor vs normal (RNA) · all GIGYF2 data types