GHSR

Across TCGA patient cohorts, GHSR protein abundance is significantly associated with the RNA expression of many other genes, with 308 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GHSR-associated genes across cancer lineages are NIN, PCNX1, and TRADD. Each is linked with GHSR in more than 1 cancer types. Because this analysis shows association rather than direction, both GHSR-to-partner and partner-to-GHSR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GHSR versus NIN in GBM, with a Pearson correlation of 0.88.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHSR→partner) and Y-score (partner→GHSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NIN →	+0.810	+0.980	<.001	.002	3	1
GBM	PCNX1 →	+0.392	+0.980	.003	.002	3	1
GBM	TRADD →	-1.223	-1.039	.002	<.001	3	1
GBM	NFKBIB →	-0.553	-1.153	.002	.006	3	1
GBM	PEX11G →	-0.562	-1.053	.002	<.001	3	1
GBM	ZNF85 →	+1.006	+1.259	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 308 associations by consensus.

GHSR vs NIN — GBM

Explore this scatter interactively →