GHSR

Across TCGA patient cohorts, GHSR mutation is significantly associated with the RNA expression of many other genes, with 2,201 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GHSR-associated genes across cancer lineages are MRPS15, HMG20B, and ORC6. Each is linked with GHSR in more than 2 cancer types. Because this analysis shows association rather than direction, both GHSR-to-partner and partner-to-GHSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS15 grouped by GHSR-low versus GHSR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHSR→partner) and Y-score (partner→GHSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPS15 →	+0.447	+2.606	.001	<.001	3	3
SKCM	HMG20B →	+1.015	+3.468	<.001	.002	3	3
UCEC	ORC6 →	+0.628	+2.831	.001	.001	3	3
SKCM	ANKRD39 →	+0.537	+2.591	.002	.006	3	3
LUAD	H3P13 →	+0.174	+3.420	<.001	.007	3	2
UCEC	NDUFAF5 →	+0.399	+3.323	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,201 associations by consensus.

MRPS15 by GHSR expression — UCEC

Explore this box plot interactively →