GHSR

Across TCGA patient cohorts, GHSR mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GHSR-associated genes across cancer lineages are JNK_pT183_Y185, PDCD4, and HER2_pY1248. Each is linked with GHSR in more than 1 cancer types. Because this analysis shows association rather than direction, both GHSR-to-partner and partner-to-GHSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by GHSR-low versus GHSR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHSR→partner) and Y-score (partner→GHSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.176	-3.000	.013	.036	3	2
UCEC	PDCD4 →	-0.468	-2.312	.019	.034	3	2
SKCM	HER2_pY1248 →	-0.159	-3.321	.036	.010	3	2
LUSC	Ku80 →	+0.529	+2.834	.004	.035	2	2
UCEC	EGFR_pY1068 →	-0.254	-2.321	.016	.034	3	1
UCEC	eIF4E →	+0.191	+2.820	.033	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

JNK_pT183_Y185 by GHSR expression — UCEC

Explore this box plot interactively →