GHSR

Across TCGA cell cohorts, GHSR mutation is significantly associated with the RNA expression of many other genes, with 363 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GHSR-associated genes across cancer lineages are RNMT, SETD6, and NISCH. Each is linked with GHSR in more than 1 cancer types. Because this analysis shows association rather than direction, both GHSR-to-partner and partner-to-GHSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNMT grouped by GHSR-low versus GHSR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHSR→partner) and Y-score (partner→GHSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNMT →	+0.635	+3.385	.003	.004	3	1
LARGE_INTESTINE	SETD6 →	+0.674	+3.212	.005	.006	3	1
LARGE_INTESTINE	NISCH →	+0.796	+3.212	.001	.006	3	1
LARGE_INTESTINE	ZC2HC1A →	+0.850	+3.212	.003	.006	3	1
LARGE_INTESTINE	USP42 →	+0.624	+3.299	<.001	.004	3	1
LARGE_INTESTINE	KCNQ4 →	+1.163	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 363 associations by consensus.

RNMT by GHSR expression — LARGE_INTESTINE

Explore this box plot interactively →