GHSR

Across TCGA cell cohorts, GHSR mutation is significantly associated with the mutation status of many other genes, with 3,493 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GHSR-associated genes across cancer lineages are WNT5A, SARM1, and ATP2A3. Each is linked with GHSR in more than 3 cancer types. Because this analysis shows association rather than direction, both GHSR-to-partner and partner-to-GHSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WNT5A grouped by GHSR-low versus GHSR-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHSR→partner) and Y-score (partner→GHSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	WNT5A →	+4.807	+4.807	.008	.008	1	4
BLOOD_Leukemia	SARM1 →	+3.963	+4.662	<.001	<.001	1	3
BLOOD_Leukemia	ATP2A3 →	+2.478	+3.544	.004	.004	1	3
BLOOD_Leukemia	MARK3 →	+4.285	+4.285	.001	.001	1	3
LUNG_NSCLC_LUAD	ZNF598 →	+5.772	+5.772	.002	.002	1	3
BLOOD_Leukemia	VGLL3 →	+5.285	+4.321	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,493 associations by consensus.

WNT5A by GHSR expression — STOMACH

Explore this box plot interactively →