GHRHR

Across TCGA pan-cancer cohorts, GHRHR Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GHRHR data layer compared with 20 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher GHRHR Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GHRHR expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

BLCA, ESCA, and SKCM are the cancer types where GHRHR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	IV	0.153	0.599	.018	9	view →
ESCA	DFS	Median	III,IV	0.080	0.442	<.001	6	view →
SKCM	OS	Median	II,III,IV	0.930	0.724	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GHRHR–BLCA (OS)

Open the BLCA breakdown →