GHRHR

Across TCGA patient cohorts, GHRHR RNA expression is significantly associated with the go_rna of many other GO terms, with 7,020 significant associations in total. STAD shows the largest number of these associations.

The most reproducible GHRHR-associated GO terms across cancer lineages are Polyamine metabolic process, Cellular response to unfolded protein, and Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Each is linked with GHRHR in more than 16 cancer types. Because this analysis shows association rather than direction, both GHRHR-to-partner and partner-to-GHRHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Polyamine metabolic process grouped by GHRHR-low versus GHRHR-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GHRHR→partner) and Y-score (partner→GHRHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Polyamine metabolic process →	+0.071	+0.234	<.001	<.001	3	17
ESCA	Cellular response to unfolded protein →	+0.056	+0.119	<.001	.006	2	15
STAD	Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay →	+0.045	+0.128	<.001	<.001	3	14
TGCT	Negative regulation of developmental growth →	+0.037	+0.170	.001	<.001	3	14
STAD	Regulation of double-strand break repair →	+0.043	+0.150	<.001	<.001	3	13
STAD	Obsolete regulation of dosage compensation by inactivation of X chromosome →	+0.055	+0.169	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,020 associations by consensus.

Polyamine metabolic process by GHRHR expression — ESCA

Explore this box plot interactively →