GHRHR

Across TCGA patient cohorts, GHRHR mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GHRHR-associated genes across cancer lineages are Notch1, p38-MAPK_pT180_Y182, and p90 RSK_pT359_S363. Each is linked with GHRHR in more than 1 cancer types. Because this analysis shows association rather than direction, both GHRHR-to-partner and partner-to-GHRHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by GHRHR-low versus GHRHR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHRHR→partner) and Y-score (partner→GHRHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.212	+2.817	.004	.036	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.506	-3.000	.031	.036	3	1
UCEC	p90 RSK_pT359_S363 →	+0.282	+2.817	.007	.036	3	1
UCEC	p90 RSK →	+0.221	+2.183	.027	.035	3	1
UCEC	TIGAR →	+0.177	+2.196	.027	.034	3	1
UCEC	p62 Lck ligand →	+0.431	+2.817	.011	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Notch1 by GHRHR expression — UCEC

Explore this box plot interactively →