GHRHR

Across TCGA cell cohorts, GHRHR mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GHRHR-associated genes across cancer lineages are OR2J2, OR10W1, and ACSM6. Each is linked with GHRHR in more than 1 cancer types. Because this analysis shows association rather than direction, both GHRHR-to-partner and partner-to-GHRHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2J2 grouped by GHRHR-low versus GHRHR-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHRHR→partner) and Y-score (partner→GHRHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR2J2 →	+0.026	+4.981	<.001	.008	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+3.562	<.001	.002	3	1
LARGE_INTESTINE	ACSM6 →	+0.024	+3.584	<.001	.002	3	1
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TBR1 →	+0.040	+3.333	<.001	.009	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR2J2 by GHRHR expression — CNS

Explore this box plot interactively →