GHRH

Across TCGA pan-cancer cohorts, GHRH mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GHRH data layer compared with 18 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GHRH mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GHRH expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

UCEC, CCRCC, and HNSC are the cancer types where GHRH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.481	0.944	.003	20	view →
CCRCC	OS	Quartile	All	0.954	0.710	.011	16	view →
HNSC	OS	Median	II,III,IV	0.953	1.000	.019	7	view →
PDAC	OS	Tertile	III,IV	0.328	1.000	.013	4	view →
LUAD	DFS	Quartile	III,IV	0.384	0.814	.026	3	view →
LSCC	OS	Tertile	All	0.909	0.721	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GHRH–UCEC (DFS)

Open the UCEC breakdown →