GHDC

Across TCGA pan-cancer cohorts, GHDC mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GHDC data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GHDC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GHDC expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where GHDC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.472	1.000	.001	44	view →
CCRCC	DFS	Quartile	III,IV	0.797	0.406	.005	12	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	6	view →
PDAC	DFS	Median	II,III,IV	0.716	0.830	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GHDC–LSCC (DFS)

Open the LSCC breakdown →