GH2

Across TCGA patient cohorts, GH2 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GH2-associated genes across cancer lineages are Melanocytes, Hepatocytes, and CD8+ Tcm. Each is linked with GH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GH2-to-partner and partner-to-GH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Melanocytes grouped by GH2-low versus GH2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GH2→partner) and Y-score (partner→GH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Melanocytes →	+0.069	+3.353	.029	.005	3	2
STAD	Hepatocytes →	+0.010	+2.980	.017	.033	3	2
UCEC	CD8+ Tcm →	+0.024	+2.520	.015	.024	3	2
UCEC	pDC →	+0.067	+2.180	.008	.036	2	2
UCEC	Epithelial cells →	-0.084	-3.321	.025	.010	1	2

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Melanocytes by GH2 expression — SKCM

Explore this box plot interactively →