GGT7

Across TCGA patient cohorts, GGT7 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGT7-associated genes across cancer lineages are Rictor_pT1135, Notch1, and eIF4G. Each is linked with GGT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GGT7-to-partner and partner-to-GGT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by GGT7-low versus GGT7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGT7→partner) and Y-score (partner→GGT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rictor_pT1135 →	+0.192	+2.832	.016	.034	3	2
UCEC	Notch1 →	+0.162	+3.087	.004	<.001	3	2
UCEC	eIF4G →	+0.359	+3.321	.004	.009	3	1
UCEC	JNK2 →	+0.290	+3.196	<.001	.009	3	1
UCEC	mTOR_pS2448 →	-0.139	-1.980	.021	.030	3	1
UCEC	p62 Lck ligand →	+0.362	+3.321	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Rictor_pT1135 by GGT7 expression — SKCM

Explore this box plot interactively →