GGT1

Across TCGA patient cohorts, GGT1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGT1-associated genes across cancer lineages are ACVRL1, PCNA, and PI3K-p110-a. Each is linked with GGT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GGT1-to-partner and partner-to-GGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by GGT1-low versus GGT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGT1→partner) and Y-score (partner→GGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.177	-3.150	.005	.019	3	2
UCEC	PCNA →	+0.235	+2.584	.019	.011	3	2
UCEC	PI3K-p110-a →	-0.164	-2.584	.046	.011	3	2
UCEC	ERK2 →	+0.255	+3.459	.004	.005	2	2
UCEC	GATA6 →	-0.217	-2.985	.005	.034	3	1
UCEC	INPP4B →	-0.425	-3.169	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ACVRL1 by GGT1 expression — UCEC

Explore this box plot interactively →