GGT1

Across TCGA cell cohorts, GGT1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GGT1-associated genes across cancer lineages are SLC15A5, ATXN3L, and RESP18. Each is linked with GGT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GGT1-to-partner and partner-to-GGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC15A5 grouped by GGT1-low versus GGT1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGT1→partner) and Y-score (partner→GGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC15A5 →	+0.103	+5.196	<.001	.005	3	2
LUNG_NSCLC_LUAD	ATXN3L →	+0.470	+4.371	<.001	.005	3	1
OVARY	RESP18 →	+0.038	+5.196	<.001	.005	3	1
LARGE_INTESTINE	SGIP1 →	+0.504	+3.626	.005	.003	3	1
LARGE_INTESTINE	SIX3 →	+0.623	+3.374	<.001	.005	3	1
LARGE_INTESTINE	ABCG4 →	+0.334	+3.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SLC15A5 by GGT1 expression — OVARY

Explore this box plot interactively →