GGT1

Across TCGA cell cohorts, GGT1 mutation is significantly associated with the mutation status of many other genes, with 2,491 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GGT1-associated genes across cancer lineages are DENND4B, USP13, and MYH9. Each is linked with GGT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GGT1-to-partner and partner-to-GGT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DENND4B grouped by GGT1-low versus GGT1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGT1→partner) and Y-score (partner→GGT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DENND4B →	+3.238	+4.960	<.001	<.001	1	4
LUNG_NSCLC_LUAD	USP13 →	+3.339	+4.662	.003	.003	1	3
LUNG_NSCLC_LUAD	MYH9 →	+3.339	+4.662	.003	.003	1	3
LUNG_NSCLC_LUAD	PKN1 →	+4.339	+4.339	.009	.009	1	3
LUNG_NSCLC_LUAD	APCDD1 →	+5.339	+4.772	.004	.004	1	3
BLOOD_Leukemia	GOLGA3 →	+3.145	+3.932	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,491 associations by consensus.

DENND4B by GGT1 expression — BLOOD_Leukemia

Explore this box plot interactively →