GGPS1

Across TCGA patient cohorts, GGPS1 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGPS1-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and INPP4B. Each is linked with GGPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GGPS1-to-partner and partner-to-GGPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GGPS1-low versus GGPS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGPS1→partner) and Y-score (partner→GGPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.293	-2.700	.003	.006	3	2
COAD	eIF4E →	+0.258	+2.820	.002	.035	3	2
UCEC	INPP4B →	-0.359	-2.459	.005	.018	3	2
UCEC	Annexin-1 →	+0.614	+3.169	.003	.018	3	2
UCEC	ATM →	-0.567	-2.459	.001	.019	3	2
COAD	Caspase-7-cleavedD198 →	+1.887	+3.330	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

EGFR_pY1068 by GGPS1 expression — UCEC

Explore this box plot interactively →