GGNBP2

Across TCGA patient cohorts, GGNBP2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGNBP2-associated genes across cancer lineages are 4E-BP1, p62 Lck ligand, and P-Cadherin. Each is linked with GGNBP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GGNBP2-to-partner and partner-to-GGNBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by GGNBP2-low versus GGNBP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGNBP2→partner) and Y-score (partner→GGNBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.229	+1.837	.014	.014	3	3
UCEC	p62 Lck ligand →	+0.332	+2.331	.003	.003	3	2
UCEC	P-Cadherin →	-0.142	-2.690	.004	.006	2	3
UCEC	PDCD4 →	-0.448	-1.736	.006	.007	3	2
UCEC	ATM →	-0.473	-3.000	.002	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.609	+2.019	.003	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

4E-BP1 by GGNBP2 expression — UCEC

Explore this box plot interactively →