GGH

Across TCGA pan-cancer cohorts, GGH mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of GGH’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where GGH mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types GGH is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

CCRCC, COAD, and LUAD are the cancer types where GGH tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GGH mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	−1.904	<.001	12	view →
COAD	Male	III,IV	+1.074	<.001	10	view →
LUAD	All	III,IV	+0.673	<.001	9	view →
LSCC	Male	All	+0.796	<.001	8	view →
HNSC	All	III,IV	+0.327	<.001	8	view →
PDAC	Female	II,III,IV	+0.538	<.001	6	view →
OV	All	All	+0.657	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

GGH–CCRCC

Open the CCRCC breakdown →