GGH

Across TCGA patient cohorts, GGH mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGH-associated genes across cancer lineages are MEK1, Notch1, and c-Met_pY1235. Each is linked with GGH in more than 1 cancer types. Because this analysis shows association rather than direction, both GGH-to-partner and partner-to-GGH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GGH-low versus GGH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGH→partner) and Y-score (partner→GGH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.475	+3.000	.024	.036	3	1
UCEC	Notch1 →	+0.204	+2.817	.012	.036	3	1
UCEC	c-Met_pY1235 →	+0.089	+3.000	.037	.037	3	1
UCEC	TFRC →	+0.967	+3.000	.001	.037	1	2
UCEC	Di-Ras3 →	-0.174	-3.000	.042	.037	2	1
UCEC	4E-BP1_pS65 →	-0.263	-2.986	.020	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MEK1 by GGH expression — UCEC

Explore this box plot interactively →