GGH

Across TCGA cell cohorts, GGH mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GGH-associated genes across cancer lineages are MMP26, OR2AJ1, and FRRS1L. Each is linked with GGH in more than 1 cancer types. Because this analysis shows association rather than direction, both GGH-to-partner and partner-to-GGH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by GGH-low versus GGH-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGH→partner) and Y-score (partner→GGH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MMP26 →	+0.026	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR2AJ1 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	FRRS1L →	+0.040	+4.807	<.001	.006	3	1
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	ACER1 →	+0.072	+4.145	.006	.001	3	1
LARGE_INTESTINE	NPY2R →	+0.003	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MMP26 by GGH expression — BLOOD_Myeloma

Explore this box plot interactively →