GGCX

Across TCGA patient cohorts, GGCX mutation is significantly associated with the RNA expression of many other genes, with 4,212 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGCX-associated genes across cancer lineages are DEFB1, LINC02336, and MYO19. Each is linked with GGCX in more than 2 cancer types. Because this analysis shows association rather than direction, both GGCX-to-partner and partner-to-GGCX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB1 grouped by GGCX-low versus GGCX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGCX→partner) and Y-score (partner→GGCX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DEFB1 →	-1.958	-1.836	<.001	.001	3	3
LUAD	LINC02336 →	+0.787	+4.481	<.001	.009	3	2
UCEC	MYO19 →	+0.513	+4.152	<.001	<.001	3	2
UCEC	SNX3P1Y →	+0.054	+3.571	<.001	.009	3	2
COAD	CRELD2 →	+0.543	+3.352	.003	.005	3	2
UCEC	RPL23AP82 →	+0.500	+3.283	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,212 associations by consensus.

DEFB1 by GGCX expression — UCEC

Explore this box plot interactively →