GGCX

Across TCGA patient cohorts, GGCX mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGCX-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and EGFR_pY1068. Each is linked with GGCX in more than 2 cancer types. Because this analysis shows association rather than direction, both GGCX-to-partner and partner-to-GGCX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by GGCX-low versus GGCX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGCX→partner) and Y-score (partner→GGCX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.742	+2.019	<.001	.005	3	3
UCEC	eEF2 →	+0.296	+1.362	.019	.037	3	2
UCEC	EGFR_pY1068 →	-0.372	-3.523	<.001	<.001	3	2
UCEC	ERK2 →	+0.218	+2.000	.001	.029	3	2
COAD	JNK_pT183_Y185 →	-0.281	-3.000	.028	.035	3	2
UCEC	MEK1 →	+0.426	+3.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Caspase-7-cleavedD198 by GGCX expression — UCEC

Explore this box plot interactively →