GGCX

Across TCGA cell cohorts, GGCX mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GGCX-associated genes across cancer lineages are CELA2A, CNBD1, and SSMEM1. Each is linked with GGCX in more than 1 cancer types. Because this analysis shows association rather than direction, both GGCX-to-partner and partner-to-GGCX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CELA2A grouped by GGCX-low versus GGCX-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGCX→partner) and Y-score (partner→GGCX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CELA2A →	+0.045	+4.684	<.001	.002	3	2
BLOOD_Leukemia	CNBD1 →	+0.190	+3.234	.001	.008	3	2
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1
LARGE_INTESTINE	MS4A14 →	+0.016	+4.054	<.001	.004	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CENPVL3 →	+0.212	+3.920	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CELA2A by GGCX expression — SKIN

Explore this box plot interactively →