GGCT

Across TCGA pan-cancer cohorts, GGCT mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GGCT data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GGCT mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GGCT expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where GGCT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.850	0.497	.005	20	view →
CCRCC	OS	Quartile	All	0.925	0.773	.024	6	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	6	view →
HNSC	OS	Tertile	II,III,IV	0.942	1.000	.033	4	view →
LUAD	OS	Quartile	III,IV	0.931	0.396	.023	2	view →
UCEC	DFS	Median	All	0.928	0.794	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GGCT–LSCC (DFS)

Open the LSCC breakdown →