GGCT

Across TCGA patient cohorts, GGCT mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGCT-associated genes across cancer lineages are FASN, EGFR_pY1068, and ER-alpha. Each is linked with GGCT in more than 1 cancer types. Because this analysis shows association rather than direction, both GGCT-to-partner and partner-to-GGCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by GGCT-low versus GGCT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGCT→partner) and Y-score (partner→GGCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.532	+2.700	.002	.006	3	2
UCEC	EGFR_pY1068 →	-0.228	-2.000	.044	.032	3	1
UCEC	ER-alpha →	-0.792	-3.156	.032	.018	3	1
UCEC	A-Raf_pS299 →	-0.118	-3.321	.028	.010	3	1
UCEC	Gab2 →	+0.429	+2.000	.007	.032	3	1
UCEC	GAPDH →	+0.487	+2.000	.044	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

FASN by GGCT expression — UCEC

Explore this box plot interactively →