GGA3

Across TCGA pan-cancer cohorts, GGA3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GGA3 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher GGA3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GGA3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where GGA3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	III,IV	0.330	0.977	.006	13	view →
LUAD	OS	Quartile	All	1.000	0.884	.011	7	view →
LSCC	OS	Tertile	All	0.891	0.762	.047	1	view →
HNSC	DFS	Median	III,IV	0.939	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GGA3–PDAC (OS)

Open the PDAC breakdown →