GGA2

Across TCGA pan-cancer cohorts, GGA2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GGA2 data layer compared with 17 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GGA2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GGA2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

COAD, PDAC, and HNSC are the cancer types where GGA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.879	1.000	.019	66	view →
PDAC	OS	Quartile	II,III,IV	0.955	0.751	.008	10	view →
HNSC	DFS	Median	IV	0.535	0.842	.004	8	view →
GBM	OS	Median	All	0.283	0.505	.011	7	view →
CCRCC	DFS	Tertile	III,IV	0.537	0.871	.026	5	view →
LUAD	OS	Quartile	II,III,IV	0.746	0.433	.032	2	view →
LSCC	DFS	Tertile	III,IV	0.436	0.859	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GGA2–COAD (DFS)

Open the COAD breakdown →