GGA2

Across TCGA cell cohorts, GGA2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GGA2-associated genes across cancer lineages are CPLX4, XKR3, and KCNA5. Each is linked with GGA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GGA2-to-partner and partner-to-GGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPLX4 grouped by GGA2-low versus GGA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGA2→partner) and Y-score (partner→GGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CPLX4 →	+0.024	+4.392	.004	.004	3	1
LARGE_INTESTINE	XKR3 →	+0.042	+3.793	<.001	.007	3	1
SKIN	KCNA5 →	+0.021	+3.766	.003	.004	3	1
SKIN	PRSS37 →	+0.057	+3.781	<.001	.003	3	1
SKIN	KCNC2 →	+0.028	+3.878	.003	.003	3	1
SKIN	PTGDR →	+0.017	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CPLX4 by GGA2 expression — LARGE_INTESTINE

Explore this box plot interactively →